期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：5
页码：1771-1775
DOI：10.1073/pnas.71.5.1771
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Metabolism of tyrosine was examined in mice, some of which had been treated with an inhibitor of aromatic-L-amino-acid decarboxylase. The results of the study indicate that as the plasma and tissue levels of tyrosine are elevated, decarboxylation to tyramine becomes the predominant route of metabolism. At the highest dose of tyrosine used (1.5 g/kg), it was found that 42% of the administered dose was decarboxylated within 6 hr and only 11.5% was metabolized by the tyrosine aminotransferase pathway.
