期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：5
页码：2118-2122
DOI：10.1073/pnas.71.5.2118
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Periodic spikes of decreased optical density were recorded in cell suspensions of Dictyostelium discoideum. Spike formation as well as changes in the redox state of cytochrome b are facultatively and independently coupled to an oscillating system which is under developmental control and presumably underlies signal transmission in aggregating cells. Cyclic AMP triggers a double response, the slow component resembling the spikes formed during spontaneous oscillations. The fast component shows characteristics of the chemotactic response to cyclic AMP. The receptor system is suggested to sense changes of cyclic AMP concentration in time. Cyclic AMP pulses interact with the oscillating system, resulting in phase shift or suppression of spike formation, and in the induction of oscillations in an early stage of development before the onset of spontaneous oscillations. Continuous flow application of cyclic AMP does not change frequency up to flow rates which extinguish oscillations.
