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  • 标题:X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA
  • 本地全文:下载
  • 作者:P J Bond ; R Langridge ; K W Jennette
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1975
  • 卷号:72
  • 期号:12
  • 页码:4825-4829
  • DOI:10.1073/pnas.72.12.4825
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.
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