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  • 标题:Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains
  • 本地全文:下载
  • 作者:E A Kabat ; T T Wu ; H Bilofsky
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1976
  • 卷号:73
  • 期号:12
  • 页码:4471-4473
  • DOI:10.1073/pnas.73.12.4471
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Examination of the sequences of the first complementarity-determining segments of the light chains of two IgM cold agglutinins agains blood group I, four monoclonal IgM antibodies against IgG proteins, and of three Bence Jones proteins provides clues for predicting which residues contribute to antibody specificity and indicates that these predictions may be tested by evaluating recovery of antibody activity and specificity when various light chains are recombined with homologous and heterologous heavy chains.
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