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  • 标题:Microviscosity modulation during the cell cycle of neuroblastoma cells
  • 本地全文:下载
  • 作者:S W de Laat ; P T van der Saag ; M Shinitzky
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1977
  • 卷号:74
  • 期号:10
  • 页码:4458-4461
  • DOI:10.1073/pnas.74.10.4458
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase, and increased again during the G2 phase. These findings imply a direct role of the cell membrane fluidity in regulation of the cell cycle.
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