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  • 标题:Molecular properties of the nerve growth factor secreted in mouse saliva
  • 本地全文:下载
  • 作者:R A Murphy ; J D Saide ; M H Blanchard
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1977
  • 卷号:74
  • 期号:7
  • 页码:2672-2676
  • DOI:10.1073/pnas.74.7.2672
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Some molecular properties of the nerve growth factor (NGF) secreted in mouse saliva and that present in submandibular glands have been measured for comparison with previously studied forms of NGF. The results show that mouse saliva contains two biologically active NGF species. One has a molecular weight near 114,000, and the other, a molecular weight of 13,000. The larger form is being continuously degraded to yield the smaller one, probably as a result of a slow enzymatic process. Virtually identical results were obtained with crude submandibular gland extracts. The larger NGF is neither the well-known 7S NGF nor 2.5S NGF. Our results indicate that the larger salivary NGF is the naturally occurring form of NGF as it exists in the submandibular gland and as it is secreted in saliva. Its biological properties and its function in saliva, if any, remain to be elucidated.
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