期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1977
卷号：74
期号：7
页码：3023-3027
DOI：10.1073/pnas.74.7.3023
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The heterogenetic Forssman antigen is a glycosphingolipid, a ceramide pentasaccharide with the structure GalNAc1[->]3GalNAc{beta}1[->]3Gal1[->]4Gal{beta}1[->]4Glc[->]ceramide. Forssman-positive animals are capable of synthesizing this compound in tissues or in erythrocytes, in contrast to the Forssman-negative species, including humans, which are incapable of adding the last carbohydrate in the sequence of the Forssman antigen, namely GalNAc. The Forssman glycolipid and its precursor globoside were examined in twenty-one samples of surgically extirpated gastrointestinal mucosa and tumors derived therefrom. The results revealed that a few patients had chemically and immunologically detectable levels of the Forssman glycolipid as a normal component of their gastrointestinal mucosa (F+ population); in contrast, the majority of patients did not contain this glycolipid in their normal mucosa (F- population). Whereas the F- population included blood groups A, B, and O, the F+ population did not correspond to blood group A. The Forssman status in tumors taken from the F+ or F- population showed the following striking features: (i) all tumors derived from F- mucosa possessed Forssman glycolipid, whereas (ii) none of the tumors originating in F+ mucosa contained Forssman glycolipid. Globoside, the immediate precursor of Forssman antigen, was distributed equally among F+ and F- mucosa and the tumors derived therefrom. Thus, the expression of Forssman antigen in gastrointestinal mucosa appears akin to that of an isoantigen. Furthermore, the Forssman antigen that appears in tumors of the F- population could represent a human tumor-associated antigen. In view of the strong crossreactivity of Forssman antigen with blood group A determinants, the appearance of Forssman antigen in human tumors could be related to the "A-like antigen" (or "neo-A antigen") of human tumors reported previously [Hakomori, S., Koscielak, J., Black, K. J. & Jeanloz, R. W. (1967) J. Immunol. 98, 31-38; Hakkinen, I. (1970) J. Natl. Cancer Inst. 44, 1183-1193].
关键词：Forssman-positive and Forssman-negative populations ; tumor ; globoside ; blood group
