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  • 标题:Crystallographic studies of bovine beta2-microglobulin
  • 本地全文:下载
  • 作者:J W Becker ; J A Ziffer ; G M Edelman
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1977
  • 卷号:74
  • 期号:8
  • 页码:3345-3349
  • DOI:10.1073/pnas.74.8.3345
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Crystals of the bovine milk protein lactollin yield x-ray diffraction data extending to a resolution of 2.8 A. Lactollin is a bovine analogue of beta2-microglobulin, a protein that is homologous in amino acid sequence to the constant domains of immunoglobulins and is the light chain of the human and murine major histocompatability antigens. The protein crystallizes in the orthorhombic space group P2(1)2(1)2(1) with a = 77.4, b = 47.9, and c = 34.3 A. The unit cell parameters and physical chemical solution studies indicate that the molecule exists in the crystal and in solution as a single polypeptide chain of 12,000 daltons.
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