期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：12
页码：6098-6101
DOI：10.1073/pnas.75.12.6098
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The 10-nm filaments of baby hamster kidney (BHK-21) cells, when examined either in the form of native filament caps or polymerized in vitro, are long tubes of protein 8--10 nm in diameter. They contain about 42% alpha-helix, which, on the basis of x-ray diffraction data, is arranged in a coiled-coil conformation characteristic of proteins of the alpha type. The known structural properties such as morphology, dimensions, subunit composition, and ultrastructure of this fibrous protein are very similar to those of the mammalian epidermal keratin filament, to which it may therefore be related.
