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  • 标题:ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12
  • 本地全文:下载
  • 作者:T A Bickle ; C Brack ; R Yuan
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1978
  • 卷号:75
  • 期号:7
  • 页码:3099-3103
  • DOI:10.1073/pnas.75.7.3099
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.
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