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  • 标题:Complementary carrier peptide synthesis: general strategy and implications for prebiotic origin of peptide synthesis
  • 本地全文:下载
  • 作者:J A Walder ; R Y Walder ; M J Heller
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1979
  • 卷号:76
  • 期号:1
  • 页码:51-55
  • DOI:10.1073/pnas.76.1.51
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A method for peptide synthesis is proposed based on a template-directed scheme that parallels that of the native ribosomal mechanism. In this procedure, peptide bond formation is facilitated by the juxtaposition of aminoacyl and peptidyl oligonucleotide carriers bound adjacent to one another on an oligonucleotide template. The general strategy of the synthesis and relevant model studies are described. The scheme provides an intrinsic mechanism by which oligonucleotides can direct the synthesis of polypeptides in the absence of protein or ribosomal machinery and, as such, suggests a model for the origin of prebiotic protein synthesis.
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