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  • 标题:Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg
  • 本地全文:下载
  • 作者:W M Generoso ; K T Cain ; M Krishna
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1979
  • 卷号:76
  • 期号:1
  • 页码:435-437
  • DOI:10.1073/pnas.76.1.435
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine, and benzo[a]pyrene treatments; and no difference was found for x-ray treatment.
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