期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：12
页码：6120-6123
DOI：10.1073/pnas.76.12.6120
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Highly purified calf brain cathepsin D (EC 3.4.23.5 ) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.
