期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1979
卷号：76
期号：4
页码：1532-1536
DOI：10.1073/pnas.76.4.1532
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Natural antamanide, a cyclic decapeptide from Amanita phalloides, has been shown to have the same conformation for the backbone and comparable side groups as the biologically active synthetic [Phe4, Val6]antamanide. Packing in the crystal is quite different for the two compounds. Large channels with a polar lining are formed in the crystals of [Phe4, Val6]antamanide, whereas in natural antamanide large channels in the crystal are completely surrounded by the lipophilic side groups of the Pro, Phe, and Ala residues. Antamanide, C64H78N10O10{middle dot}8H2O{middle dot}X, crystallizes in space group P212121 with a = 15.88 A, b = 34.88 A, and c = 13.61 A.
