期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：1
页码：649-652
DOI：10.1073/pnas.77.1.649
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The development of the putative neurotransmitter substance P (SP) in rat dorsal root ganglion (DRG) was defined in vivo. The sixth cervical DRG of newborn rats contained 70 pg of SP, and the ganglionic content increased 5.5-fold during the first 5 weeks of life. Forelimb amputation partially prevented the normal developmental increase of SP in the sixth cervical DRG destined to innervate that limb. Conversely, treatment with nerve growth factor (NGF) increased both ganglionic SP and total ganglion protein. Moreover, NGF administration prevented the failure of SP development that followed amputation, suggesting that NGF may mediate the limb-DRG interaction. However, treatment with antiserum to NGF failed to significantly inhibit development of ganglion SP. Consequently, neonatal ganglia may remain responsive to NGF, without requiring the protein for survival. SP appears to be an excellent index of the maturation of neurons in dorsal root ganglia.
