期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：7
页码：4374-4378
DOI：10.1073/pnas.77.7.4374
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The embryonic development of the optic nerve of the zebrafish, Brachydanio rerio, was studied by three-dimensional computer reconstruction from serial section electron micrographs. Growing fibers from retinal ganglion cells had growth cones in contact with more mature fibers from adjacent cell bodies. In the observed growth pattern, the optic fibers immediately behind the eye were ordered in such a way that the rectangular coordinates of the fiber positions were approximately proportional to the polar coordinates of their cell body positions. We suggest that this transformation is achieved by a simple following mechanism that translates the time and position of ganglion cell differentiation into a well-defined spatial organization within the optic nerve.
