期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：8
页码：4788-4792
DOI：10.1073/pnas.77.8.4788
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The loss of the lectin-like activity of a 26,000-dalton carbohydrate-binding protein (CBP-26) results in the loss of aggregation competence and cell-cell cohesiveness in developing cells of Dictyostelium discoideum. The lesion responsible for this phenotype behaves like a mutation in the structural gene for CBP-26, maps in linkage group II, and has been designated cbpA1. In aggregation-competent revertants, the degree of aggregation competence and cell-cell cohesiveness is directly related to the specific activity of CBP-26. Thus, CBP-26 appears to play an essential role in cell aggregation through the cell-cell cohesion process.
