期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1980
卷号：77
期号：9
页码：5437-5440
DOI：10.1073/pnas.77.9.5437
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1 ) were found to suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree as well as the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins was not found to replace the need for a functional cyclooxygenase and, in some instances, could be shown to diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.
