期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：1
页码：270-273
DOI：10.1073/pnas.78.1.270
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The chemical potential ({micro}L,b) of a ligand L bound to a protein or enzyme can be rigorously defined, and this paper describes some of its properties in relation to other thermodynamic parameters, with emphasis on thermodynamic parameters that may be used in the elucidation of the mechanism of biological free energy transduction. Free energy transduction involves the transfer of free energy from one molecule to another, and the actual transfer may often occur while both molecules are bound to the transducer enzyme, which means that {micro}L,b for one bound ligand increases at the expense of {micro}L,b for the other. The free energy change for the overall reaction may be very small, and it is not possible to express the phenomenon of transfer, in thermodynamic terms, without the explicit use of {micro}L,b as a parameter.
关键词：solution thermodynamics ; protein binding ; membranes ; ion transport
