期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：6
页码：3450-3453
DOI：10.1073/pnas.78.6.3450
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The repair of DNA double-strand breaks in Escherichia coli cells irradiated with gamma rays occurs only after new proteins are synthesized in response to damage introduced in the genome DNA. One protein whose synthesis is thus induced is the recA protein, and previous work has shown that recA- cells do not repair double-strand breaks. However, inducing recA protein by treating cells with nalidixic acid does not induce repair of double-strand breaks, so this repair requires more than the presence of the recA protein. When repair of double-strand breaks is blocked, the genome DNA is degraded by an endonuclease-like action. Evidence is presented to show that the inducible inhibition of DNA degradation after x-irradiation [Pollard, E. C. & Randall, E. P. (1973) Radiat. Res. 55, 265] is probably caused by the inducible repair of DNA double-strand breaks.
