期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1981
卷号：78
期号：6
页码：3605-3609
DOI：10.1073/pnas.78.6.3605
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A number of lipophilic amines of diverse chemical structure, including antihistaminics, local anesthetics, and chloroquine, were found to exhibit similar kinetics in inhibiting the infection of BHK cells by vesicular stomatitis virus. The inhibition occurred prior to both primary and secondary RNA transcription but following transfer from the cell surface to an intracellular site, presumed to be the lysosomes. A similar inhibition, by these agents, of infection by Sendai, influenza strain WSN, and Semliki Forest viruses suggested a lysosomal involvement in infection by these viruses as well.
