期刊名称:Proceedings of the National Academy of Sciences
印刷版ISSN:0027-8424
电子版ISSN:1091-6490
出版年度:1981
卷号:78
期号:6
页码:3858-3862
DOI:10.1073/pnas.78.6.3858
语种:English
出版社:The National Academy of Sciences of the United States of America
摘要:Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr 49,000 recognized by two monoclonal antibodies. OKT6 and NA1/34, and is associated with a Mr 12,000 subunit that crossreacts serologically with beta 2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr 46,000 protein associated with a small subunit distinct from beta 2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a beta 2-microglobulin-associated glycoprotein of Mr 43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoietic cell lines tested.