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  • 标题:The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.
  • 本地全文:下载
  • 作者:E J Bellefroid ; D A Poncelet ; P J Lecocq
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1991
  • 卷号:88
  • 期号:9
  • 页码:3608-3612
  • DOI:10.1073/pnas.88.9.3608
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:We have previously shown that the human genome includes hundreds of genes coding for putative factors related to the Kruppel zinc-finger protein, which regulates Drosophila segmentation. We report herein that about one-third of these genes code for proteins that share a very conserved region of about 75 amino acids in their N-terminal nonfinger portion. Homologous regions are found in a number of previously described finger proteins, including mouse Zfp-1 and Xenopus Xfin. We named this region the Kruppel-associated box (KRAB). This domain has the potential to form two amphipathic alpha-helices. Southern blot analysis of "zoo" blots suggests that the Kruppel-associated box is highly conserved during evolution. Northern blot analysis shows that these genes are expressed in most adult tissues and are down-regulated during in vitro terminal differentiation of human myeloid cells.
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