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  • 标题:Immobilization of DNA for scanning probe microscopy
  • 本地全文:下载
  • 作者:D P Allison ; L A Bottomley ; T Thundat
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1992
  • 卷号:89
  • 期号:21
  • 页码:10129-10133
  • DOI:10.1073/pnas.89.21.10129
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.
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