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  • 标题:Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.
  • 本地全文:下载
  • 作者:Y Kasai ; J R Nambu ; P M Lieberman
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1992
  • 卷号:89
  • 期号:8
  • 页码:3414-3418
  • DOI:10.1073/pnas.89.8.3414
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.
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