期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1997
卷号：94
期号：21
页码：11274-11278
DOI：10.1073/pnas.94.21.11274
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Interactions between the cAMP receptor protein (CRP) and the carboxy-terminal regulatory domain (CTD) of Escherichia coli RNA polymerase subunit were analyzed at promoters carrying tandem DNA sites for CRP binding using a chemical nuclease covalently attached to . Each CRP dimer was found to direct the positioning of one of the two subunit CTDs. Thus, the function of RNA polymerase may be subject to regulation through protein-protein interactions between the two subunits and two different species of transcription factors.
