期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：15
页码：8898-8903
DOI：10.1073/pnas.95.15.8898
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Expression of peroxisome proliferator-activated receptor (PPAR) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPAR/retinoid x receptor ligands, and FA all up-regulate PPAR and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPAR is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
