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  • 标题:Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI
  • 本地全文:下载
  • 作者:G. Michael Iverson ; Edward J. Victoria ; David M. Marquis
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1998
  • 卷号:95
  • 期号:26
  • 页码:15542-15546
  • DOI:10.1073/pnas.95.26.15542
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Anticardiolipin (aCL) autoantibodies are associated with thrombosis, recurrent fetal loss, and thrombocytopenia. Only aCL found in autoimmune disease require the participation of the phospholipid binding plasma protein {beta}2 glycoprotein I ({beta}2GPI) for antibody binding and now are called anti-{beta}2GPI. The antigenic specificity of aCL affinity purified from 11 patients with high titers was evaluated in an effort to better understand the pathophysiology associated with aCL. Seven different recombinant domain-deleted mutants of human {beta}2GPI, and full length human {beta}2GPI (wild-type), were used in competition assays to inhibit the autoantibodies from binding to immobilized wild-type {beta}2GPI. Only those domain-deleted mutants that contained domain 1 inhibited the binding to immobilized wild-type {beta}2GPI from all of the patients. The domain-deleted mutants that contained domain 1 inhibited all aCL in a similar but not identical pattern, suggesting that these aCL recognize a similar, but distinguishable, epitope(s) present on domain 1.
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