期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：26
页码：15758-15762
DOI：10.1073/pnas.95.26.15758
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：To elucidate the role of thyroid hormone receptors (TRs) 1 and {beta} in the development of hearing, cochlear functions have been investigated in mice lacking TR1 or TR{beta}. TRs are ligand-dependent transcription factors expressed in the developing organ of Corti, and loss of TR{beta} is known to impair hearing in mice and in humans. Here, TR1-deficient (TR1-/-) mice are shown to display a normal auditory-evoked brainstem response, indicating that only TR{beta
