期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：6
页码：3117-3121
DOI：10.1073/pnas.95.6.3117
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. In the present study, we show that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte chemoattractant protein-1 (MCP-1). Astrocytic release of {beta}-chemokines, which are relatively less selective for monocytes, including RANTES, macrophage inflammatory protein-1, and macrophage inflammatory protein-1{beta
