期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：13
页码：7276-7281
DOI：10.1073/pnas.96.13.7276
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Cell proliferation and terminal differentiation are mutually exclusive in most cell lineages. The b-zip transcription factor CCAAT/enhancer-binding protein (C/EBP) induces proliferation arrest and differentiation in many cell types, suggesting that both activities are linked. Here we show that C/EBP-mediated proliferation arrest and differentiation pathways can be separated by the E7 oncoprotein of the "high-risk" human papilloma virus 16. The E7 oncoprotein overrides C/EBP-mediated cell cycle withdrawal without compromising the transactivation activity of C/EBP or its ability to participate in differentiation. Uncoupling of both pathways depends on the casein kinase II site of the oncoprotein but not on its ability to neutralize pocket proteins or the cyclin-dependent kinase inhibitor protein p21. Our results suggest a bifurcation of C/EBP-mediated proliferation arrest and differentiation pathways.
