期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：14
页码：7752-7755
DOI：10.1073/pnas.96.14.7752
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：There are differences between human individuals and between mouse strains in levels of {micro} opiate receptor ({micro}OR) expression, responses to painful stimuli, and responses to opiate drugs. One of the best candidates for contributing to these differences is variation at the {micro}OR gene locus. Support for this idea comes from analyses of the human and murine {micro}OR genes. Assessments of individual differences in human {micro}OR expression add further support. Studies with mice, including knockout-transgenic, quantitative trait locus, and strain-comparison studies, also strongly support the possibility that {micro}OR gene alleles would be strong candidates for contributing to individual differences in human nociception and opiate drug responses. This paper reviews current analyses of the murine and human {micro}OR genes, their important variants, and correlations between these variants and opiate influences on pain.
