期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：17
页码：9891-9896
DOI：10.1073/pnas.96.17.9891
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：{gamma} -Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtypes with distinct temporal and spatial patterns of expression and distinct properties that presumably underlie a precise role for each subtype. The newest member of this gene family is the {theta} subunit. The deduced polypeptide sequence is 627 amino acids long and has highest sequence identity (50.5%) with the {beta}1 subunit. Within the rat striatum, this subunit coassembles with 2, {beta}1, and {gamma}1, suggesting that {gamma}-aminobutyric acid type A receptors consisting of arrangements other than {beta} + {gamma
