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  • 标题:Compactness of the denatured state of a fast-folding protein measured by submillisecond small-angle x-ray scattering
  • 本地全文:下载
  • 作者:Lois Pollack ; Mark W. Tate ; Nicholas C. Darnton
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1999
  • 卷号:96
  • 期号:18
  • 页码:10115-10117
  • DOI:10.1073/pnas.96.18.10115
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Time-resolved small-angle x-ray scattering was used to measure the radius of gyration of cytochrome c after initiation of folding by a pH jump. Submillisecond time resolution was obtained with a microfabricated diffusional mixer and synchrotron radiation. The results show that the protein first collapses to compact denatured structures before folding very fast to the native state.
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