期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：2
页码：651-656
DOI：10.1073/pnas.96.2.651
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4+ T cells of intranasally immunized mice displayed higher OVA-specific proliferative responses and elevated production of interferon {gamma
