期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：21
页码：12144-12149
DOI：10.1073/pnas.96.21.12144
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Oscillations in intracellular free calcium concentration ([Ca2+]i) occur spontaneously in immature neurons of the developing cerebral cortex. Here, we show that developing murine cortical neurons exhibit calcium oscillations in response to direct activation of the mGluR5 subtype of the group I metabotropic glutamate receptor (mGluR). In contrast, other manipulations that elicit [Ca2+]i increases produce simple, nonoscillatory changes. Furthermore, we find that spontaneous oscillatory [Ca2+]i activity is blocked by antagonists of group I mGluRs, suggesting a specific role for mGluR activation in the promotion of oscillatory [Ca2+]i dynamics in immature cortical neurons. The oscillatory pattern of [Ca2+]i increases produced by mGluR activation might play a role in the regulation of gene expression and the control of developmental events.
