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  • 标题:Virulence and transmission success of the malarial parasite Plasmodium falciparum
  • 本地全文:下载
  • 作者:Rhian E. Hayward ; Bela Tiwari ; Karen P. Piper
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1999
  • 卷号:96
  • 期号:8
  • 页码:4563-4568
  • DOI:10.1073/pnas.96.8.4563
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Virulence of Plasmodium falciparum is associated with the expression of variant surface antigens designated PfEMP1 (P. falciparum erythrocyte membrane protein 1) that are encoded by a family of var genes. Data presented show that the transmission stages of P. falciparum also express PfEMP1 variants. Virulence in this host-parasite system can be considered a variable outcome of optimizing the production of sexual transmission stages from the population of disease-inducing asexual stages. Immunity to PfEMP1 will contribute to the regulation of this trade-off by controlling the parasite population with potential to produce mature transmission stages.
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