期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2016
卷号：7
期号：12
页码：4692-4696
出版社：University of Mohammed Premier Oujda
摘要：A simple, efficient and eco-friendly protocol has been developed for the condensation of various aromatic aldehydes, cyclopentanone and urea of thiourea using animal bone meal as a heterogeneous catalyst. The remarkable catalytic activity and reusability of animal bone meal widens its applicability in Biginelli reaction with good to excellent yields for synthesis of pyrimidinone derivatives. Green organic synthesis is needed to face current environmental pollution. Many synthetic approaches have been developed to produce substituted pyrimidinone. This original method generated good yields and therefore presents the opportunity for the development of clean and environmentally-friendly catalytic processes. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles, straightforward procedure, and a reduction in catalyst toxicity. This method has several advantages such as high yields of 66–94 %, short reaction times of 15–60 min, easy purification processes, and methodological simplicity. This method provides new opportunities for the rapid screening of a wide range of compounds, either for the development of new drugs or total synthesis of natural products.
关键词：Heterocyclic compounds; Animal Bone Meal; Biginelli reaction; Heterogeneous catalysis
