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文章基本信息

  • 标题:Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
  • 作者:Aurelie Nguimmo-Metsadjio ; Barbara Atogho-Tiedeu ; Jean Jacques Noubiap
  • 期刊名称:Journal of Health, Population and Nutrition
  • 电子版ISSN:2072-1315
  • 出版年度:2017
  • 卷号:36
  • 期号:1
  • 页码:12
  • DOI:10.1186/s41043-017-0087-z
  • 语种:English
  • 出版社:Springer Verlag
  • 摘要:

    Objective

    This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population.

    Method

    This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters.

    Results

    The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic ( p = 0.50) and allelic frequencies ( p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups.

    Conclusion

    The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.

  • 关键词:Obesity ; Genetic association ; TCF7L2 ; rs7903146 (C/T) polymorphism ; Sub-Saharan Africa ; Cameroon
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