文章基本信息
- 标题：Expression of miR-126 and its potential function in coronary artery disease
- 本地全文：下载
- 作者：Xiaoyan Wang ; Yajun Lian ; Xin Wen 等
- 期刊名称：African Health Sciences
- 印刷版ISSN：1680-6905
- 电子版ISSN：1729-0503
- 出版年度：2017
- 卷号：17
- 期号：2
- 页码：474-480
- DOI：10.4314/ahs.v17i2.22
- 出版社：Makerere University Medical School（Uganda)
- 摘要：
Objective: This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis.
Methodology: A total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR. ELISA was used to measure plasma level of placenta growth factor (PLGF).
Results: The results showed that the miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects ( P P
Conclusion: miR-126 may serve as a novel biomarker for CAD.
- 关键词：miR-126; PLGF; PCR; coronary artery disease; atherosclerosis
