摘要：Low 25-hydroxyvitamin D (25OHD) levels ( 0.99). There was no between-group difference in change in the Hb concentrations (− 0.04 g/dL [95%CI:-0.53 to 0.45 g/dL]; P = 0.87). Results regarding anemia risk and Hb concentrations were similar in the subgroup of patients with chronic kidney disease (vitamin D group: n = 26; placebo group: n = 23). Moreover, results did not differ substantially when data analysis was restricted to patients with deficient baseline 25OHD levels. A daily vitamin D supplement of 4000 IU did not reduce anemia prevalence in patients with advanced HF. Data challenge the clinical relevance of vitamin D supplementation to increase Hb levels. The study was registered at EudraCT (No. 2010–020793-42) and clinicaltrials.gov ( NCT01326650 ).
关键词：Vitamin D supplementation ; Hemoglobin ; Anemia ; 25-Hydroxyvitamin D ; 1,25-Dihydroxyvitamin D ; Chronic heart failure
