标题：On the estimation of survival time of cardio-vascular disease patients with random number of myocardial infarctions using parametric and semi-parametric methods
其他标题：On the estimation of survival time of cardio-vascular disease patients with random number of myocardial infarctions using parametric and semi-parametric methods
期刊名称：Electronic Journal of Applied Statistical Analysis
电子版ISSN：2070-5948
出版年度：2010
卷号：3
期号：1
页码：1-17
DOI：10.1285/i20705948v3n1p1
语种：English
出版社：University of Salento
摘要：Cardiovascular disease (CVD) is the leading cause of mortality in developing countries. CVD studies that involve the recording of two or more distinct and well-defined myocardial infarctions (MI) occurring over time in the same patient give rise to recurrent event data. In recent years a variety of fruitful statistical methods have been proposed for the analysis of recurrent events in medical areas. The present article is concerned with the estimation of the survival time of CVD patients, in the presence of recurrent myocardial infarctions followed by a terminal event death, under three different possibilities, i.e., the inter-event times between heart attacks follow gamma distribution, the number of heart attacks for an individual occur with time independent constant intensity λ , which is varying across individuals, and the hazard rates for the recurrent heart attacks vary from different attacks for the same individual. Cox's proportional hazard model has also been applied to study the effect of age at the time of first MI and the number of MI's experienced by the patient, on the survival time of CVD patients. Prior to that proportionality assumption has been tested. The methods are applied to a CVD patients data set obtained from Dr.Ram Manohar Lohia (R.M.L) Hospital, Delhi. The major advantage of developing models for estimating the survival time of CVD patients is that the treatment comparisons can be designed so that the expected survival time of new CVD patients can be predicted and improved after the first MI. Also it can be used as a baseline for further studies.
关键词：Cardio-vascular disease;;Myocardial Infarction;Recurrent Event;Survival Time
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