出版社：The International Institute for Science, Technology and Education (IISTE)
摘要：Toxicity profile on serum electrolytes, hepatic and renal function indices on rats administered with mixture of ethanol/potash extract of sorghum bicolor leaf sheath were investigated. The ethanol/potash extract was dried and re-suspended in distilled water and the following quantities were administered orally to the albino rat per kg body weight: 1000, 2000 and 3000mg; while 0.9% normal saline was served to the control group. The blood was collected through cardiac puncture under chloroform anesthesia after 14 days. There after, the sera were analyzed for sodium (Na + ), potassium, (K + ),chloride (Cl - ) ion, urea, creatinine, total protein, total bilirubin and cholesterol levels. Serum sodium levels, (176-297 mmol/L) were significantly (p<0.05) increased following extract treatments, while potassium ion decreased (6.54-4.00mmol/L). The extract increased chloride ion concentration (95.8-99.0mmol/L). The serum value for creatinine (0.08-0.32mmol/L) and urea (3.16-38mmol/L) increased progressively; while cholesterol (0.96-0.19mmol/L) and total protein (54.13-17.27g/L) levels, decreased significantly (p<0.05) when compared to the control values. No significant change was observed in the value obtained for bilirubin except at dose level of 3000mg/kg body weight. There was a progressive decrease in body weight after 14days administration of the extract. The result showed that the mixture of ethanol/potash extract of sorghum bicolor leaf sheath has been observed in rats under the conditions of this study to be toxic. Keyword: Sorghum bicolor, ethanol/potash, electrolytes, kidney, liver.
