出版社：The International Institute for Science, Technology and Education (IISTE)
摘要：Chromatographic studies of Cryptolepis oblongifolia yielded a triterpene fatty acid (Oleanyl Erucoate) which was identified through spectroscopic means. The inhibitory effect of the isolated compound on PLA 2 of Naja nigricollis venom was investigated. The 13 CNMR of the isolated compound showed carbonyl functional group and oleanane type of structure while EIMS analysis revealed that, the compound was Oleanyl Erucoate with molecular weight of [M+1] 735. The triterpene fatty acid inhibited the PLA 2 in a dose dependent fashion with an inhibition binding constant ( ki ) of 1.74 mg/mL. The activity of this compound might provide a scientific basis for the local use of Cryptolepis oblongifolia in traditional medicine for the treatment of inflammation or contribute in the development of novel drugs that could serve as potential antivenin.
