标题：Hereditary and environmental factors causing total joint replacement due to hip and knee osteoarthritis – a twin registry based prospective cohort study
出版社：Norsk forening for epidemiologi - The Norwegian Epidemiological Association
摘要：The relative contribution of genetic factors and more modifiable environmental factors to a clinicallyrelevant osteoarthritis (OA) diagnosis is unkown. In this paper we present an ongoing study on the geneticcontribution to total joint replacement (TJR) due to hip and knee OA and effects of lifestyle and lifestylerelated conditions on TJR due to OA. We have linked data on incident OA from the Norwegian ArthroplastyRegistry were l with the Norwegian Twin Registry on the National ID number in 2014, thus obtaining apopulation based cohort of same-sex twins born 1915-60. Data on height, weight and lifestyle were selfreportededin questionnaires conducted between 1978 and 1992. The monozygotic (MZ) and dizygotic(DZ) concordances as well as the genetic contribution vs. contribution of more modifiable, environmentalfactors to arthroplasty will be examined in separate analyses for the hip and the knee joint. The samplecomprised N=18058 twins (N=3803 MZ and N=5226 DZ pairs) including N=9650 (53.4%) females and amean (SD) age of 38 (12.3) years at questionnaire response. Some preliminary analyses have been performedshowing a higher concordance for TJR due to hip OA among MZ (0.36) than DZ twins (0.16), which maybe consistent with a genetic contribution to hip OA. TJR due to hip OA may be determined by geneticfactors. Results for the knee joint as well as final results from hereditary analyses and co-twin controlanalyses of will be published consecutively from 2016.
其他摘要：The relative contribution of genetic factors and more modifiable environmental factors to a clinically relevant osteoarthritis (OA) diagnosis is unkown. In this paper we present an ongoing study on the genetic contribution to total joint replacement (TJR) due to hip and knee OA and effects of lifestyle and lifestyle related conditions on TJR due to OA. We have linked data on incident OA from the Norwegian Arthroplasty Registry were l with the Norwegian Twin Registry on the National ID number in 2014, thus obtaining a population based cohort of same-sex twins born 1915-60. Data on height, weight and lifestyle were selfreporteded in questionnaires conducted between 1978 and 1992. The monozygotic (MZ) and dizygotic (DZ) concordances as well as the genetic contribution vs. contribution of more modifiable, environmental factors to arthroplasty will be examined in separate analyses for the hip and the knee joint. The sample comprised N=18058 twins (N=3803 MZ and N=5226 DZ pairs) including N=9650 (53.4%) females and a mean (SD) age of 38 (12.3) years at questionnaire response. Some preliminary analyses have been performed showing a higher concordance for TJR due to hip OA among MZ (0.36) than DZ twins (0.16), which may be consistent with a genetic contribution to hip OA. TJR due to hip OA may be determined by genetic factors. Results for the knee joint as well as final results from hereditary analyses and co-twin control analyses of will be published consecutively from 2016.
