文章基本信息

标题：In vitro Interaction of Metronidazole and Mebendazole with Copper (II) and Chromium (III) in Aqueous Media
其他标题：In vitro Interaction of Metronidazole and Mebendazole with Copper (II) and Chromium (III) in Aqueous Media
作者：A. T. M. Z. Azam ; F. Siraji ; M. S. Amran 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2012
卷号：4
期号：1
页码：173
DOI：10.3329/jsr.v4i1.7599
语种：English
出版社：Rajshahi University
摘要：The interaction of metronidazole, an antiprotozoal agent and mebendazole, an important anthelmentic agent with Cu (II) and Cr(III) ions have been studied in aqueous systems at a fixed temperature of 37±0.5°C and at different pH values. It has been found that metronidazole and mebendazole form stable 1:1 complexes with Cu(II), but a less stable complex with Cr(III) ion. The studies were performed by electroanalytical and spectrophotometric methods. Spectral studies helped to detect initial complexation between the species. Conductometric titration indicated the nature of interaction and the stoichiometries of complexation. The conductometric study also indicated the formation of complexes of various molar ratios viz 1:2, 4:1, 3:1, 1:2, 1:3 and 1:4. etc. along with 1:1 complexes at various pH conditions. Similar types of complexation were observed by Job’s plots at various pH values. The Ardon’s spectroscopic method confirmed the 1:1 complexation and the values of stability constant were calculated using Ardon’s plot. Complexation at molar ratios 1:3 and 1:4 can not be ruled out. Keywords: Metronidazole; Mebendazole; Cu(II); Cr(III); Ardon’s plot; Complexation. © 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v4i1.7599J. Sci. Res. 4 (1), 173-181 (2012)
关键词：Pharmaceutical Chemistry;Metronidazole; Mebendazole; Cu(II); Cr(III); Ardons plot; Complexation.