出版社：Norsk forening for epidemiologi - The Norwegian Epidemiological Association
摘要：ABSTRACTA tissue bank is established in our department on a total of 659 persons whereof 341 are included in theNordic data base on somatic chromosome damage in humans. Genotyping of susceptibility genes relevantto the exposures of the cohort is an ongoing undertaking in our laboratory. GST's and mEH have beengenotyped for 80 persons so far, CYP's for 20 persons. When the mean number of chromatide breaks and ofcells with aberrations were related to genotypes no statistical difference could be observed between thegenotypes for either parameter. No difference in cytogenetic damage between exposed and referents orbetween smokers and non-smokers were identified for the two separate occupational studies these 80persons represent. The results of the various cytogenetic endpoints were trichotomized and compared to thegenotype distribution. Although not statistically significant, the observed trend with higher percentage ofpersons with polymorphic GSTp1 in particular, but also for GSTq1 and mEH (exon 4) in the group withhigh frequency of chromosome aberrations will be interesting to follow. For further follow-up studies, anested case-control study within the cohort would give a more rapid and less expensive approach thananalysing each study separately as a traditional case-control study. As high frequency of chromosomaldamage is associated with cancer development, the hypothesis to be tested would be whether genetic polymorphismsfor the most appropriate susceptibility genes could be an explanatory factor for this association.
Loading...
