期刊名称：Journal of Theoretical and Applied Information Technology
印刷版ISSN：1992-8645
电子版ISSN：1817-3195
出版年度：2017
卷号：95
期号：19
页码：5158
出版社：Journal of Theoretical and Applied
摘要：Petri net is a formalism which is very beneficial for biologists. The analytical and simulation abilities of Petri net may assist the elaboration of experiments because it can be used to test hypotheses and collect related information. This paper is a survey about PN formalisms regarding gene regulatory network (complex systems of genes, proteins and other types of molecules), considering the advantages and disadvantages of each method. In addition, a model of genetic regulatory network is demonstrated for the response of carbon starvation stress in E. coli. It was previously represented by differential equation; however, it has been transformed into Hybrid functional Petri net (HFPN) model. The HFPN formalism has yielded its suitability for modeling the carbon starvation response network in E. coli cells. Therefore, by utilizing this model on a current available tool, and by using simulations, results have been gained which are identical to previous studies
关键词：Hybrid functional Petri Net; Gene Regulatory Network; E. coli; Modeling and Simulation
