摘要：Context and Aims: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercus brantii 's nut on clinical, endoscopic, and pathological findings of patients with dyspepsia. Patients and Methods: In this randomized, double-blind clinical trial, patients with symptomatic dyspepsia who had an endoscopic evaluation for dyspepsia were included and randomized into two groups. One Group (A) received drug extract with a dose of 100 mg twice a day for 10 days. Group B, as a control group, received placebo. Immediately and 2 months after intervention, the patients were followed up, and the characteristics of their dyspepsia (severity and frequency), endoscopic and pathologic findings were reevaluated and compared. Results: In this trial, 13 and ten patients participated in the study in Groups A and B, respectively. Two months after intervention, ten (76.9%) and six (60%) participants referred for follow-up and endoscopic evaluation. There were no significant changes in clinical presentations after intervention ( P > 0.05). Two months after intervention, clinical presentations including severity and frequency of epigastric pain had significant decrease in Group A and endoscopic evaluation indicated significant improvement in Group A ( P 0.05). Conclusions: The findings of this trial indicated that hydroalcoholic extract of Q. brantii 's nut could have delayed significant proper effect on clinical and endoscopic presentations of patients with dyspepsia. We recommend that this study should be considered as pilot one in this field. The results could be used as baseline data for more interventional studies. More surveys are needed to investigate the mechanism of extract action at molecular basis.
