摘要:Backgrounds: Marriages and establishing a family is one of the most important events in the life of each person. It has significant effects on personal and social health, if it occurs with sufficient knowledge in the proper conditions. The aim of this study is to determine the effect of pre-marriage instruction on the knowledge and health attitudes of the couples attending the pre-marriage counseling classes. Materials and Methods: This pre and post quasi-experimental study was conducted on 250 couples attending the pre-marriage counseling classes. The required information was collected using an autonomous questionnaire designed based on the research objectives. The questionnaire included three parts: Demographic information, knowledge (27 questions) and attitude (18 questions. The questionnaire was filled out before and after the pre-marriage counseling program, which was presented as lectures. The effect of the instructional program was analyzed using a statistical test. Results: The results showed that 83.2% of the couples had poor knowledge, 16% average, and 0.8% had good knowledge before the intervention. After the intervention, 60.4% of couples had poor knowledge, 31.6% average and 8% had good knowledge. The results also revealed that that the difference in mean scores of knowledge and attitudes regarding reproductive health, family planning, genetic diseases and disabilities was statistically significant ( P Conclusions: Despite the mean scores of knowledge and attitude of the couples had increased after the instructional intervention, the increase in knowledge level was not very high. So the knowledge score of the couples increased just 4.3%, and only 8% of the couples had good knowledge after the instructional intervention. Therefore, to achieve a relatively stable behavior change in individuals and improving the health level of the young couples, it is recommended that more attention pay to the quality of the instructional classes.